Protocoled thrombolytic therapy for frostbite improves phalangeal salvage rates
نویسندگان
چکیده
منابع مشابه
Use of Intra-arterial Thrombolytic Therapy for Acute Treatment of Frostbite in 62 Patients with Review of Thrombolytic Therapy in Frostbite
Amputations are common after severe frostbite injuries, often mediated by postinjury arterial thrombosis. Since 1994, the authors have performed angiography to identify perfusion deficits in severely frostbitten digits and treated these lesions with intraarterial infusion of thrombolytic agents, usually combined with papaverine to reduce vasospasm. A retrospective review was performed of patien...
متن کاملReduction of the incidence of amputation in frostbite injury with thrombolytic therapy.
HYPOTHESIS Thrombolytic therapy will decrease the incidence of amputation when administered within 24 hours of exposure. DESIGN Single institution retrospective review of clinical outcomes and resource use. SETTING Burn unit of a tertiary academic referral center. PATIENTS From 2001 to 2006, patients with severe frostbite admitted within 48 hours of injury underwent digital angiography an...
متن کاملReducing Amputation Rates After Severe Frostbite.
Evidence-Based Answer In patients with severe frostbite, tPA plus a prostacyclin may be used to decrease the risk of digital amputation. (Strength of Recommendation [SOR]: B, based on a single randomized controlled trial [RCT].) tPA can be used alone and is associated with lower amputation rates compared with local wound care. (SOR: C, based on lower-quality cohort studies.) A 2011, open-label ...
متن کاملThrombolytic therapy for stroke
Stroke is a common condition affecting approximately 110,000 people every year in England alone. It is the third leading cause of death and the single largest cause of adult physical disability [1]. A third of individuals who have a stroke are left with a long-term disability that may include weakness, sensory impairment and loss of cognitive and communication skills, depending on the regions o...
متن کاملThrombolytic therapy.
Thrombolytic therapy, which involves the administration of agents designed to increase fibrinolytic capacity, has been utilized in respiratory medicine for more than 50 years. A variety of agents have been used to effect thrombolysis, including urokinase plasminogen activator (uPA) and streptokinase. Tissue plasminogen activator (tPA) has also been used to effect thrombolysis. Both uPA and tPA ...
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ژورنال
عنوان ژورنال: Burns & Trauma
سال: 2020
ISSN: 2321-3876
DOI: 10.1093/burnst/tkaa008